Swedish Mammography Cohort clinical subcohort
A clinical examination of women in the Swedish mammography cohort living in Uppsala was conducted between 2003 and 2009. The cycle of re-examination for this group started in year 2015 and is ongoing. For women living in Västerås a clinical examination were conducted between 2010 and 2019. The examination includes collection of clinical samples and additional information.
Swedish Mammography Cohort - clinical subcohort Uppsala
From 2003 through 2009 participants in the Swedish Mammography Cohort below age 85 years and living in the town of Uppsala were randomly selected and invited to participate in a clinical subcohort. Of the 8,311 invited women 65% answered the received diet, lifestyle, and physical activity questionnaire and 60%, 5,032 women, participated in the health examination. Samples are available for 5022 women. The health examination included weight, height, waist, hip, and blood pressure measurements, and body composition measurement using a dual energy X-ray absorptiometry (DEXA) scan. Samples of fasting blood and urine in addition to adipose tissue were also collected at the health exam.
A subset of the women visiting the clinic completed additional food and physical activity questionnaires in addition to wearing a physical activity monitor and complete a 7-day activity record. A second subset of women visiting the clinic completed a questionnaire on sun exposure in conjunction with a blood sample collected both during winter and summer months.
A second round of health examination including biological sample collection (blood, urine, adipose tissue, but also faeces), and diet and lifestyle questionnaire, is ongoing for this clinical subcohort since January 2015. The second round also includes a one-day food diary and a cognitive interview.
Home health examination Uppsala
From March 2012 to March 2013 1,030 women in the Swedish Mammography Cohort over age 85 years and living in Uppsala County received an invitation letter to participate in a validated cognitive test phone interview, complete a food frequency questionnaire, and receive a home health examination. 305 women, 29%, were examined at home including weight, height, waist, hip, and blood pressure measurements, physical function test, and the Mini Mental State Examination (MMSE). Blood, urine, adipose tissue, and fecal samples were also collected.
Swedish Mammography Cohort - clinical subcohort Västerås
Between 2010 and 2019 women in the Swedish Mammography Cohort living in the county of Västmanland received a diet, health and lifestyle questionnaire and a one-day food diary with an invitation to participate in a health examination. During the nine years a total of 2,630 women visited the clinic in Västerås, of which 1,062 were living with a man participating in the male clinical subcohort of the Cohort of Swedish Men. The health examination included weight, height, waist, hip, blood pressure measurement and body composition measurement using a bio-electrical impedance scale (Tanita, Tokyo, Japan). Samples of fasting blood, urine, fecal sample and adipose tissue were also collected at the health exam.
A second round is planned to start during 2021 following the procedure for the first round, but adding a cognitive interview and a DEXA scan for all participants at their visit.