Cohorts and biorepository in SIMPLER
Cohorts within SIMPLER are multidisciplinary longitudinal projects on the association of lifestyle and genetic factors with morbidity and mortality in middle-aged and elderly women and men. These large population-based prospective cohorts were established more than 30 years ago for women and more than 20 years ago for men, both have repeated over time assessments of exposures.
In the left menu you find more detailed information on each cohort and their variables:
- SMC, Swedish Mammography Cohort
- COSM, Cohort of Swedish Men
- SMC clinical subcohorts
- COSM clinical subcohorts
The Swedish Mammography Cohort and the Cohort of Swedish Men are based on food frequency questionnaires including questions on health and life style. Each of these two cohorts have clinical subcohorts for sampling of clinical measurements including body composition, physical performance, cognitive function and collection of different biological samples, including blood, urine, stool and fat tissue. Additional information on outcomes is accomplished through matching with national, regional and local registers with high completeness of diagnoses.
A description of the cohorts is published by Harris et al. in 2013, The Swedish mammography cohort and the cohort of Swedish men: study design and characteristics of two population-based longitudinal cohorts. Please note a wrong number in figure 1 for SMC at 1997 follow up after exclusions, it should be 38 984 instead of 39 984.
| Questionnaire | SMC | COSM |
|---|---|---|
| 1987 | 61 433 | |
| 1997 | 38 984 | 45 906 |
| 2008 Health questionnaire | 30 621 | 29 503 |
| 2009 Lifestyle questionnaire | 25 332 | 26 156 |
| 2019 Health questionnaire | 19 081 | 18 901 |
| 2019 Lifestyle questionnaire | 14 922 | 16 166 |
| SMC clinical subcohort Uppsala | SMC clinical subcohort Västerås | COSM clinical subcohort Västerås | COSM clinical subcohort Örebro | |
|---|---|---|---|---|
| Cycle 1 | N=5 032, collected 2003-2009 | N=2 630, collected 2010-2019 | N=4 754, collected 2010-2019 | N=602, collection started 2014 and ongoing |
| Cycle 2 | N=1 232, collection started May 2015 and ongoing | Preliminary start 2021 | Preliminary start 2021 | |
| 85+, home visit | N=307, collected 2012-2013 | N=87, collected 2013-2014 | ||
| *Sampling at Karolinska Institutet | *N=82, collected 2014 | *N=25, collected 2014 |
*Residents in Västmanland or Örebro County at start of Swedish Mammography Cohort 1987 and Cohort of Swedish Men 1997, who had moved to and were living in Stockholm at time of invitation to participate in the clinical subcohort.
| SMC, 1987-2019 | COSM, 1997-2019 | SUM | |
|---|---|---|---|
| Death | 28 698 | 20 866 | 49 564 |
| Cancer (-2018) | 15 441 | 12 935 | 28 376 |
| CVD | 41 615 | 31 511 | 73 126 |
| IHD | 12 173 | 12 724 | 24 897 |
| Ami | 6 735 | 6 872 | 13 607 |
| Stroke | 8 967 | 6 808 | 15 775 |
| Heart failure | 11 533 | 8 750 | 20 283 |
| Diabetes | 9 928 | 8 641 | 18 569 |
| Fracture, all | 22 727 | 9 843 | 32 570 |
| Hip fracture | 7 563 | 2 668 | 10 231 |
| Cataract extraction | 19 250 | 10 460 | 29 710 |