Biological samples

For the clinical subcohorts fasting whole blood, serum, plasma, buffy coat, urine, fat biopsies and stool samples have been collected. In addition DNA is available from approximately 32,000 females and ca 15,000 men. Approximately 40,000 DNA samples will be extracted from saliva using an extraction method that enable analysis of DNA from oral microbiota.

The samples have been collected after over-night fasting, they have been light protected during collection, serum and plasma has been aliquoted after cool centrifugation and all samples except saliva/DNA are stored in -80°C freezers.

In addition, researchers at Örebro University are since four years collecting blood samples (whole blood, plasma and serum) from COSM members with incident urological cancer (prostate, kidney, bladder and penile cancer). Urine is additionally collected from prostate cancer patients. Hitherto, samples from approximately 2,000 incident cancer cases have been collected.